This medication is used to prevent or treat gout attacks (flares). Colchicine works by decreasing swelling and lessening the build up of uric acid crystals that cause pain in the affected joint(s). This medication is also used to prevent attacks of pain in the abdomen, chest, or.
If you are taking this medication to treat symptoms due to familial Mediterranean fever, l your doctor if your condition does not improve or if it worsens.
Your doctor may recommend that you separate the time(s) you take your medication apart from breast-feeding. This medication passes into breast milk. While there have been no reports of harm to nursing infants, consult your doctor before breast -feeding.
Limit alcohol and ask your doctor, pharmacist, or dietitian about avoiding foods high in purines that may worsen gout (such as anchovies, bacon, beer, sardines, organ meats including liver / kidneys ).
Colchicine consists of pale yellow scales or powder; it darkens on exposure to light. Colchicine is soluble in water, freely soluble in alcohol, and slightly soluble.
Absolute bioavailability is reported to be approximay 45%
They are often the first signs of toxicity and may indicate that the colchicine dose needs to be reduced or therapy stopped. Gastrointestinal disorders are the most common adverse reactions with colchicine. These include diarrhea, nausea, vomiting, and abdominal pain.
Combining these dual inhibitors with colchicine in patients with renal or hepatic impairment has resulted in life-threatening or fatal colchicine toxicity. Patients with renal or hepatic impairment should not be given colchicine capsules with drugs that inhibit both P- glycoprotein and CYP3A4 inhibitors.
Dose reduction or alternatives should be considered for the prophylaxis of gout flares in patients with severe hepatic impairment.
Colchicine crosses the human placenta.
Colchicine is an oral drug used to treat or prevent gout symptoms, or to treat familial Mediterranean fever. Learn about side effects, warnings, and more.
Colchicine oral tablet doesn’t cause drowsiness. However, it may cause other side effects.
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Many insurance companies require a prior authorization for this drug. This means your doctor may need to get approval from your insurance company before your insurance company will pay for the prescription.
Adult dosage (ages 16–64 years):
Your doctor may start you on a lowered dose or a different dosing schedule.
Colchicine (as Colcrys or Mitigare) is a medication most commonly used to treat gout. In addition to gout, colchicine is used to treat familial Mediterranean fever.
With overdoses, colchicine becomes toxic as an extension of its cellular mechanism of action via binding to tubulin.  Cells so affected undergo impaired protein assembly with reduced endocytosis, exocytosis, cellular motility, and interrupted function of heart cells, culminating in multi-organ failure.  .
Growers of annual triploid plants not readily propagated must buy fresh seed from a supplier each year. Since most triploids do not produce pollen themselves, such plants usually require cross-pollination with a diploid parent to induce fruit production.
Historical use of colchicine, or its precursors, dates back several thousand years, with reports appearing in records from ancient Egyptians, Greeks and Arabic.
Both complications have the potential to adversely affect quality of life and increase health care utilization via rehospitalizations and additional diagnostic workup. Colchicine has potential to reduce occurrence of these complications and, since 2005, several trials have evaluated its use in the prevention of recurrent pericarditis episodes and primary prevention of PPS. Recurrent pericarditis and post-pericardiotomy syndrome (PPS) are troublesome complications for 25% to 50% of patients after acute pericarditis episodes and 10% to 40% of post-cardiac surgery patients.
The COPE, CORE and CORP trials incorporated a proton pump inhibitor in patients receiving NSAID therapy, and the LoDoCo trial will provide important long-term safety data because patients were followed for a minimum of 2 years.