Leponex Drug Information, Professional

11.23.2018 writer Emma Adderiy

Schizophrenia (treatment)—Clozapine is indicated only in the management of severely ill schizophrenic patients who have failed to respond to other neuroleptic agents or who cannot tolerate the adverse effects produced by those agents {03} {15} {23}.

Data sources include Micromedex (updated Sep 4th, 2018), Cerner Multum (updated Sep 4th, 2018), Wolters Kluwer (updated Sep 3rd, 2018) and others. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. To view content sources and attributions, please refer to our editorial policy. provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products.

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Leponex Advanced Patient Information

10.22.2018 writer Jasmine Larkins
Leponex Advanced Patient Information

Detailed drug Information for Leponex. Includes common brand names, drug descriptions, warnings, side effects and dosing information.

Breast-feeding— Clozapine may pass into breast milk and cause drowsiness, trouble in nursing, restlessness or irritability, convulsions (seizures), or heart or blood vessel problems in nursing babies.

Dizziness, especially when getting up from a lying or sitting position Less common.

Fast or irregular heartbeat; fever; low blood pressure Less common.

These can be symptoms of a very serious problem with your heart. Contact your doctor as soon as possible if you have chest pain or discomfort, a fast heartbeat, trouble breathing, or fever and chills.

If this problem continues or gets worse, check with your doctor.

Leponex, 10 years after -- a clinical review

9.21.2018 writer Jasmine Larkins
Leponex, 10 years after -- a clinical review

[Leponex, 10 years after -- a clinical review]. [Article in French]. Llorca PM(1), Pere JJ. Author information: (1)CHU Gabriel Montpied, 58, rue Montalembert.

We also address the tolerability and safety data, especially haematologic, comitial, cardiovascular and metabolic side-effects. The results of a recent randomized, parallel-group study designed to compare clozapine versus olanzapine in preventing suicide attempts seems to confirm this hypothesis.

Long-term treatment of schizophrenic patients with leponex

7.19.2018 writer John Laird

The authors studied a prolonged (3--5 years) use of leponex in 23 patients with the most progressive forms of schizophrenia (hebephrenic, paranoid and close.

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Leponex has a rather "universal" psychopharmacological effect which includes a capability of arresting acute psychoses, exerts a psychoregulating influence on the general behaviour, contacts and socio-working adaptation, distinctly alleviates the clinical signs and frequency of relapses. The study included the influence on the frequency and duration of relapses, on the dynamics of the so-called productive and negative disorders and social adaptation. The authors studied a prolonged (3--5 years) use of leponex in 23 patients with the most progressive forms of schizophrenia (hebephrenic, paranoid and close to them attack-like). Due to the absence of motor disturbances and minimum of other side-effects leponex is quite convenient for prolonged use and promotes a higher quality of remissions. The achieved data indicate that leponex possesses certain advantages compared to other neuroleptical drugs in prolonged maintenance therapy.

European Medicines Agency

4.16.2018 writer Jasmine Larkins
European Medicines Agency

Leponex. International non-proprietary name (INN) or common name. clozapine.

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Furthermore, periodic white cell counting has been required throughout treatment, being more frequent during the first 18 weeks of treatment where 88% of the cases of agranulocytosis appear. Clozapine is an antipsychotic drug with a broad range of antipsychotic activity. The low affinity for D2 receptor deserves clozapine a unique profile, as its use is not associated with extrapyramidal side effects.