Librium, the original chlordiazepoxide HCI and prototype for the benzodiazepine compounds, was synthesized and developed at Hoffmann-La Roche Inc. It is a.
Chlordiazepoxide is excreted in the urine, with 1% to 2% unchanged and 3% to 6% as conjugate. The precise mechanism of action is not known. After the drug is discontinued plasma levels decline slowly over a period of several days. Librium (chlordiazepoxide HCI) has antianxiety, sedative, appetite-stimulating and weak analgesic actions. The drug blocks EEG arousal from stimulation of the brain stem reticular formation. It takes several hours for peak blood levels to be reached and the half-life of the drug is between 24 and 48 hours.
Drowsiness, ataxia and confusion have been reported in some patients particularly the elderly and debilitated.
Librium (chlordiazepoxide) is a benzodiazepine used to treat anxiety disorders or alcohol withdrawal. l your doctor if you have side effects of Librium including: Our Librium (chlordiazepoxide) Side Effects Drug Center provides a comprehensive view of available drug information.
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Consequently, after extended therapy, abrupt discontinuation should generally be avoided and a gradual dosage tapering schedule followed. Withdrawal symptoms, similar in character to those noted with barbiturates and alcohol (convulsions, tremor, abdominal and muscle cramps, vomiting and sweating ), have occurred following abrupt discontinuance of chlordiazepoxide.
Chlordiazepoxide, trade name Librium, is a sedative and hypnotic medication of the benzodiazepine class; it is used to treat anxiety, insomnia and withdrawal.
 The half-life of chlordiazepoxide increases significantly in the elderly, which may result in prolonged action as well as accumulation of the drug during repeated administration. . The half-life of Chlordiazepoxide is 5 – 30 hours but has an active benzodiazepine metabolite (desmethyldiazepam), which has a half-life of 36 – 200 hours. Delayed body clearance of the long half-life active metabolite also occurs in those over 60 years of age, which further prolongs the effects of the drugs with additional accumulation after repeated dosing.
Like other benzodiazepines, Librium is a habit-forming, psychotropic drug. Users who are prescribed Librium for a legitimate medical purpose.
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If you are worried that an overdose is occurring in others or yourself, seek medical attention immediay.
Consumer information about the prescription drug chlordiazepoxide (Librium), used to manage anxiety disorders. Side effects, drug interactions, dosing and.
He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. Dr. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
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What else should I know about chlordiazepoxide-oral?
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