Doxepin is a tricyclic antidepressant (TCA) used to treat major depressive disorder, anxiety disorders, chronic hives, and for short-term help with trouble remaining asleep after going to bed (a form of insomnia).
 Area-under-curve levels of the drug are increased significantly when it is taken with food.  Following a single very low dose of 6 mg, peak plasma levels of doxepin are 0.854 ng/mL (3.06 nmol/L) at 3 hours without food and 0.951 ng/mL (3.40 nmol/L) at 6 hours with food. Doxepin is well- absorbed from the gastrointestinal tract but between 55 and 87% undergoes first-pass metabolism in the liver,  resulting in a mean oral bioavailability of approximay 29%. .
Learn about Sinequan (Doxepin) may treat, uses, dosage, side effects, drug interactions, warnings, patient labeling, reviews, and related medications.
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Short-term studies did not show an increase in the risk of suicidality with antidepressants compared to placebo in adults beyond age 24; there was a reduction with antidepressants compared to placebo in adults aged 65 and older. There has been a long-standing concern, however, that antidepressants may have a role in inducing worsening of depression and the emergence of suicidality in certain patients during the early phases of treatment.
A small number of children, teenagers, and young adults (up to 24 years of age) who took antidepressants ('mood elevators') such as doxepin.
It is also important information to carry with you in case of emergencies. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements.
Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community.
4 days ago Doxepin is a dibenzoxepin-derivative tricyclic antidepressant (TCA). Structurally similar to phenothiazines, TCAs contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, doxepin does not affect mood or arousal, but may cause sedation.
The primary metabolite undergoes further biotransformation to glucuronide conjugates. Extensively metabolized in the liver via the same pathways as other TCAs. N-demethylation produces a primary active metabolite, N-desmethyldoxepin (nordoxepin). In vitro studies have shown that CYP2C19 and CYP2D6 are the major enzymes involved in doxepin metabolism, and that CYP1A2 and CYP2C9 are involved to a lesser extent. Following oral administration, doxepin undergoes extensive oxidation and demethylation.
Rogowski, Cara Casseday, Meredith Perry, Bryan Knox, "LOW-DOSE DOXEPIN FORMULATIONS AND METHODS OF MAKING AND USING THE SAME." U.S.
Find patient medical information for Doxepin Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings.
If you miss a dose, take it as soon as you remember. Do not double the dose to catch up. If it is near the time of the next dose, skip themissed dose and resume your usual dosing schedule.
Choose a Condition : anxious Bipolar Depression Chronic Trouble Sleeping depression Psychotic Depressive Illness.
Follow your doctor's instructions carefully. To reduce your risk of side effects (such as drowsiness, dry mouth, dizziness ), your doctor may direct you to start this medication at a low dose and gradually increase your dose.
To prevent constipation, maintain a diet adequate in fiber, drink plenty of water, and exercise.