If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases.
Carefully check the labels of all other medicines you are using, because they may also contain acetaminophen. This combination medicine contains acetaminophen (Tylenol). It is not safe to use more than 4 grams (4,000 milligrams) of acetaminophen in one day (24 hours).
l your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also l your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Make sure your doctor knows if you are pregnant, may be pregnant, or planning to become pregnant.
Your doctor may decide not to treat you with this medication or change some of the other medicines you take. Using this medicine with any of the following medicines is not recommended.
These could be symptoms of a serious liver problem. Check with your doctor right away if you have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, unusual tiredness or weakness, or yellow eyes or skin.
Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. The amount of medicine that you take depends on the strength of the medicine.
Check with your doctor right away if you have the following symptoms of serotonin syndrome: agitation, confusion, diarrhea, excitement while talking that is not normal, fever, overactive reflexes, poor coordination, restlessness, shivering, sweating, trembling or shaking that you cannot control, or twitching. This especially includes medicines used to treat depression (such as citalopram, fluoxetine, sertraline, Cymbalta, Effexor, Lexapro, Pristiq) or medicine to treat migraine headache (such as eletriptan, frovatriptan, rizatriptan, zolmitriptan). Make sure your doctor knows about all the other medicines you are using. This medicine may increase your risk for seizures (convulsions). It may also cause a serious condition called serotonin syndrome when taken with some medicines.
When used together, the combination provides better pain relief than either medicine used alone. In some cases, you may get relief with lower doses of each medicine. Tramadol and acetaminophen combination is used to relieve pain.
If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco. Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases.
Portions of this document last updated: March 01, 2017 Original article: /drugs-supplements/tramadol-and-acetaminophen-oral-route/side-effects/drg.
Keep out of the reach of children.
But acetaminophen may cause other unwanted effects when taken in large doses, including liver damage. Although rare, use of acetaminophen has been reported to lead to liver transplantation and death, usually at high doses and when multiple acetaminophen-containing products have been used. It does not become habit-forming when taken for a long time. Acetaminophen is used to relieve pain and reduce fever in patients.
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
l your doctor if you have any sudden or strong feelings, such as feeling nervous, angry, restless, violent, or scared. Report any unusual thoughts or behaviors that trouble you, especially if they are new or get worse quickly. Make sure your caregiver knows if you have trouble sleeping, get upset easily, have a big increase in energy, or start to act reckless. l your doctor right away if you start to feel more depressed or have thoughts about hurting yourself. Let your doctor know if you or anyone in your family has tried to commit suicide. This medicine can increase thoughts of suicide.
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:.
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Get emergency help immediay if any of the following symptoms of overdose occur:
Check with your doctor right away if you have blistering, peeling, or loose skin, red skin lesions, severe acne or skin rash, sores or ulcers on the skin, or fever or chills while you are using this medicine. Serious skin reactions can occur with this medicine.
This medicine may be habit-forming. If you feel that the medicine is not working as well, do not use more than your prescribed dose. Call your doctor for instructions.
To prevent this, your doctor may direct you to take laxatives, drink a lot of fluids, or increase the amount of fiber in your diet. Using narcotics for a long time can cause severe constipation.
If you think you or someone else may have taken an overdose of this medicine, get emergency help at once. Signs of an overdose include dark urine, difficult or troubled breathing, irregular, fast or slow, or shallow breathing, nausea or vomiting, pain in the upper stomach, pale or blue lips, fingernails, or skin, pinpoint pupils of the eyes, shortness of breath, or yellow eyes or skin.
In these cases, your doctor may want to change the dose, or other precautions may be necessary. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur.
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you.
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However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses. If you miss a dose of this medicine, take it as soon as possible.
Make sure you l your doctor if you have any other medical problems, especially:. The presence of other medical problems may affect the use of this medicine.
Check the labels of all nonprescription (over-the-counter ) or prescription medicines you now take. Taking them together with this medicine may cause an overdose. If any contain acetaminophen or tramadol, check with your doctor.
This product is available in the following dosage forms:
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Check with your doctor immediay if any of the following side effects occur:
If too much of this medicine is taken for a long time, it may become habit-forming (causing mental or physical dependence) or cause an overdose. This is especially important for elderly patients, who may be more sensitive to the effects of pain medicines. Large amounts of acetaminophen may cause liver damage. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. Take this medicine only as directed by your doctor.
If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco. Using this medicine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases.
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.
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Safety and efficacy have not been established. Appropriate studies have not been performed on the relationship of age to the effects of tramadol and acetaminophen combination in the pediatric population.
Some examples of CNS depressants are antihistamines, medicine for hay fever, allergies, or colds, sedatives, tranquilizers, or sleeping medicine, prescription pain medicine or narcotics, opioids, medicine for seizures or barbiturates, muscle relaxants, or anesthetics, including some dental anesthetics. Do not drink alcoholic beverages, and check with your doctor before taking any of these medicines while you are using this medicine. Also, there may be a greater risk of liver damage if you drink three or more alcoholic beverages while you are taking acetaminophen. This medicine will add to the effects of alcohol and other CNS depressants (medicines that make you drowsy or less alert).
Ask your healthcare professional how you should dispose of any medicine you do not use.
Follow your doctor's orders or the directions on the label. If your dose is different, do not change it unless your doctor ls you to do so. The following information includes only the average doses of this medicine. The dose of this medicine will be different for different patients.
However, elderly patients are more likely to have age-related liver, kidney, or heart problems which may require caution and an adjustment in the dose for patients receiving tramadol and acetaminophen combination. Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of tramadol and acetaminophen combination in the elderly.
You may report side effects to the FDA at 1-800-FDA-1088. Call your doctor for medical advice about side effects.
Although not all of these side effects may occur, if they do occur they may need medical attention. Along with its needed effects, a medicine may cause some unwanted effects.
Also, your health care professional may be able to l you about ways to prevent or reduce some of these side effects. Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:.
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using alcohol or tobacco with certain medicines may also cause interactions to occur.
Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy or not alert. This medicine may cause some people to become dizzy, drowsy, or less alert than they are normally.
This medicine is available only with your doctor's prescription.
It is very important that your doctor check your progress at regular visits to make sure the medicine is working properly and to check for any unwanted effects.
This may help prevent worsening of your condition and reduce the possibility of withdrawal symptoms, such as anxiety, diarrhea, headache, nausea, shivering, sweating, tremors, or trouble sleeping. Your doctor may want you to gradually reduce the amount you are using before stopping it compley. Do not stop taking this medicine without first checking with your doctor.
Call your doctor right away if you have a rash, itching, hoarseness, trouble breathing, trouble swallowing, swelling of your hands, face, or mouth, or chest pain while you are using this medicine. This medicine may cause serious allergic reactions, including anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention.
Since this medicine is only used for the short-term relief of pain, physical dependence will probably not occur. When tramadol is used for a long time, it may become habit-forming (causing mental or physical dependence). Tramadol belongs to the group of medicines called opioid analgesics (narcotics). It acts in the central nervous system (CNS) to relieve pain. Physical dependence may lead to side effects when you stop taking the medicine.
For temporary relief, use sugarless candy or gum, melt bits of ice in your mouth, or use a saliva substitute. Continuing dryness of the mouth may increase the chance of dental disease, including tooth decay, gum disease, and fungus infections. Analgesics may cause dryness of the mouth. However, if dry mouth continues for more than 2 weeks, check with your dentist.
Do not keep outdated medicine or medicine no longer needed.Tramadol and klonopin combination