Recommendations for lab monitoring of atypical antipsychotics In the past, he was treated unsuccessfully with sertraline, fluoxetine, clonazepam, venlaine.
An increase in weight is thought to be associated with the actions of antipsychotics on H1and 5-HT2c receptors.7 Clozapine and olanzapine pose the highest risk of weight gain. Quetiapine and risperidone are considered of intermediate risk; aripiprazole and ziprasidone present the lowest risk( Table 1 ).5,7.
Correll CU, Manu P, Olshanskiy V, et al.
Other drugs in this category, such as clonazepam and sulthiame, do not require monitoring. Carbamazepine; Phenobarbital; Phenytoin; Valproic Acid.
This class of drugs, also known as anticonvulsants, is most often prescribed for the management of epilepsy, though some drugs may also be prescribed for other indications such as tic douloureux, myotonia, bipolar effective disorder, prophylaxis of certain varieties of migraine and of cardiac dysrhythmia. Other drugs in this category, such as clonazepam and sulthiame, do not require monitoring. All antiepileptic drugs are capable of depressing abnormal neuronal discharges in the central nervous system, which may otherwise result in seizures.
H.p.l.c. methods remain in use in laboratories which have a relatively low throughput of antiepileptic drug assays and a need to measure a variety of drugs.
Lack of adequate knowledge of matters such as the relationship between the plasma concentrations and antiepileptic and toxic effects of the drugs, not only the newer, but also the longer established ones, in particular clinical situations, remains more important than deficiencies in analytical methodology in limiting the clinical usefulness of antiepileptic drug concentration monitoring. Plasma antiepileptic drug concentration monitoring is coming to be used in a more thoughtful and critical manner.
Positive expanded benzodiazepine screen includes alpha-hydroxy-alprazolam, alpha-hydroxy-midazolam, alpha-hydroxy-triazolam, 7-aminoclonazepam.
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and the Logical Observation Identifiers Names and Codes (LOINC) Committee. The LOINC codes are, Regenstrief Institute, Inc. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/.
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