Clozapine is an antipsychotic medication that is used to treat severe schizophrenia symptoms in people who have not responded to other medications. It is also used to help reduce the risk of suicidal behavior in people with schizophrenia or similar disorders.
Clozapine has moderate interactions with at least 371 different drugs.
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Orthostatic hypotension, bradycardia, syncope.
Increased mortality in elderly with dementia -related psychosis.
Tablet, orally disintegrating (FazaClo ODT) Oral suspension (Versacloz).
Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediay.
Severe Interactions of clozapine include:
Check with your health care professional or doctor for additional medical advice, or if you have health questions, concerns or for more information about this medicine.
Clozaril (clozapine) is an antipsychotic medication that is used to treat severe schizophrenia symptoms in people who have not responded to.
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Creatine phosphokinase elevation, hyperuricemia, hyponatremia, and weight loss.
The following adverse reactions are discussed in more detail in other sections of the labeling:
The following adverse reactions have been identified during post-approval use of clozapine. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.
Clozapine, sold under the brand name Clozaril among others, is an atypical antipsychotic medication. It is mainly used for schizophrenia that does not improve following the use of other antipsychotic medications. In those with schizophrenia and schizoaffective disorder it may decrease the rate of suicidal behavior.
 . Clozapine is an antagonist at the 5-HT 2A subunit of the serotonin receptor, putatively improving depression, anxiety, and the negative cognitive symptoms associated with schizophrenia.
. Clozapine is classified as an atypical antipsychotic drug because it binds to serotonin as well as dopamine receptors.
. Clozapine and norclozapine (desmthyl-clozapine) plasma levels may also be monitored, though they show a significant degree of variation and are higher in women and increase with age.
Clozapine: learn about side effects, dosage, special precautions, and more on MedlinePlus.
Use in Older Adults:
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online ( http://www.fda.gov/Safety/MedWatch ) or by phone.
Your doctor may want to restart your medication at a lower dose. If you miss taking clozapine for more than 2 days, you should call your doctor before taking any more medication.
Clozapine controls schizophrenia but does not cure it. Continue to take clozapine even if you feel well.
Clozapine (Clozaril/FazaClo) is a medication that treats schizophrenia. Read more about Clozapine and schizophrenia treatment.
Clozapine is also FDA approved to reduce the risk of recurrent suicidal behavior in people with schizophrenia or schizoaffective disorder.
Missing doses of clozapine may increase your risk for a relapse in your symptoms.
All antipsychotics have been associated with the risk of sudden cardiac death due to an arrhythmia (irregular heart beat). To minimize this risk, antipsychotic medications should be used in the smallest effective dose when the benefits outweigh the risks. Your doctor may order an EKG to monitor for irregular heart beat.
Clozapine orally disintegrating tablets must remain in their original packaging.